Using the ESMFold model, researchers were able to digitally design and then experimentally validate nanomolar binders, a level of activity relevant for therapeutics.

The Chan Zuckerberg Initiative's structural biology center uses cryo-EM microscopes to biophysically and functionally characterize molecules designed by its AI models.

The ESMFold model is achieving state-of-the-art performance across structure prediction benchmarks, particularly for protein-protein and protein-antibody interactions.