The trend of the cost to develop a new drug increasing annually over the last 40 years is known as Eroom's Law.

Mike Nally predicts that within the next five years, the trend of rising drug development costs, known as Eroom's Law, will reverse and begin a downward trajectory for the first time in 50 years.

The lead drug molecules currently in development pipelines were designed using AI models that predate modern generative AI like ChatGPT, obscuring the true state-of-the-art capabilities.

According to Mike Nally, FDA Commissioner Macri believes the current ability to model human biology is insufficient to justify smaller or less rigorous clinical trials for drug approvals.