Bryan Johnson argues that psychedelics like psilocybin and 5-MeO-DMT should be considered anti-aging protocols. He details his self-experiments, which he claims resulted in a first-in-human observation of a metabolic reset, improved microbiome, and profound psychological rejuvenation, suggesting a new application for these powerful compounds.
The mechanism behind the psychological effects of psychedelics is explained as the dampening or 'annihilation' of the brain's default mode network (DMN). This process, observable with brain imaging, disrupts rigid thought patterns associated with ego and aging, fostering neuroplasticity and a more youthful, open-minded disposition.
The conversation explores the profound risks and philosophical consequences of using powerful tools to rewire the brain. It addresses the potential for inducing psychosis or causing users to abandon their careers and relationships, raising fundamental questions about whether a person remains the 'same' after such a dramatic internal shift.
The discussion extends beyond psychedelics to other cutting-edge anti-aging research, including mitochondrial augmentation therapy, FOXO3 gene therapy, and cellular reprogramming with Yamanaka factors. These are presented as the next major therapeutic modalities with the potential for dramatic rejuvenation effects, following the mainstream adoption of drugs like GLP-1s.
Keep pulling the thread on Bryan Johnson.