Keep pulling the thread on Bryan Johnson.
Bryan Johnson claims his psilocybin experiment resulted in a first-in-human observation of a metabolic reset, improving his blood glucose control from the 99.5th to the 99.9th percentile.
Bryan Johnson claims that 5-MeO-DMT was more effective at resetting him as a human than diet, exercise, sleep, sauna, and hyperbaric oxygen therapy combined.
Bryan Johnson cites a study where mesenchymal stem cells used for FOXO3 gene delivery resulted in rejuvenation in over 50% of tissues.
Bryan Johnson is creating organoids of his heart, liver, and lungs from his own induced pluripotent stem cells (iPSCs) to test molecules and drugs in vitro.
David Friedberg theorizes that the dosing challenge for Yamanaka factors will be solved by using cellular switches that can turn protein synthesis on or off based on real-time gene expression measurements within the cell.
Bryan Johnson states that 5-MeO-DMT is the most powerful psychedelic on the planet, estimating it is between 5 and 10 times more powerful than DMT.
Bryan Johnson conducted an experiment with psilocybin involving three doses of 25 milligrams each, which he describes as a clinical dose.
Bryan Johnson believes psilocybin is a longevity therapy based on the results of his self-experimentation.
Bryan Johnson states that psilocybin dampens the brain's default mode network, an effect that was observable using Kernel's brain interface technology.
Bryan Johnson reports that taking psilocybin also resulted in a change to his microbiome.
Bryan Johnson was told by an investor that they include clauses in their deal documents prohibiting founders from using psychedelics to mitigate the risk of them abandoning their company.
David Friedberg predicts that mitochondrial augmentation therapy will become a major new therapeutic modality that is currently under-recognized.